Can i make two APP_BASE_URL?

Features
1

can i make two APP_BASE_URL ?

2

http APP_BASE_URL is running pC + andrion,iso isnot running ,must use ssl https

but :

unraid:docker joplin + docker:postgresql + docker:Nginx Proxy Manager

https://note.name.com:8443 nginx reverse proxy 127.0.0.1:22300 give me 502 Bad Gateway

https://note.name.com:8443 nginx reverse proxy APP_BASE_URL give me Invalid origin: http://note.name.com